How to navigate
- To explore the numerical data, start by using the volcano plot (left) or PHATE landscape plot (right) below. For the volcano plot, select a parameter of interest to show the phenotype score for each gene knockout (x-axis) plotted against its corresponding statistical significance when compared to cells carrying non-targeting CRISPR sgRNAs (y-axis). For the landscape plot, select either the interphase or mitotic landscape to display how gene knockout phenotypes cluster together when the full range of extracted phenotype image parameters are accounted for. Hovering over individual data points on either plot displays the gene identity and its cluster membership below the plot. Click on a data point to navigate to a table of genes in the same cluster with links to individual gene information.
- Click the "Compare" button to the left to explore combinations of individual phenotype parameters from the primary screen.
- Use the box below to search for specific genes of interest, or click “Browse” to display a table of all gene targets which can be filtered or sorted for specific genes and parameters.
- The individual gene pages contain montages of interphase & mitotic cell images from the screen as well as additional information about each knockout. See the bottom of this page for example genes to explore.